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Unlocking Cognitive Enhancement

June 05, 2023 3 min read

Unlocking Cognitive Enhancement - Alkalife

The Benefits of Alpha-Glyceryl Phosphoryl Choline in a Super-Premium Nootropic Supplement


In today's fast-paced and demanding world, the quest for cognitive enhancement has become increasingly popular. Nootropic supplements, also known as "smart drugs," have gained significant attention due to their potential to enhance various aspects of cognitive function. Among the plethora of nootropics available, Alpha-Glyceryl Phosphoryl Choline (Alpha-GPC) has emerged as a key ingredient in super-premium formulations. This article aims to explore the benefits of Alpha-GPC as an essential component in super-premium nootropic supplements, supported by scientific evidence.

  1. Enhanced Memory and Learning: Alpha-GPC has shown promising effects on memory and learning abilities. Studies have indicated that Alpha-GPC supplementation can improve memory formation, consolidation, and retrieval, thereby enhancing cognitive performance (1). A study conducted on elderly patients with mild cognitive impairment demonstrated significant improvements in memory and cognitive function after Alpha-GPC supplementation (2). These findings highlight the potential of Alpha-GPC in supporting memory and learning processes.
  2. Neuroprotective Effects: Alpha-GPC possesses neuroprotective properties that contribute to its overall cognitive benefits. It has been observed to enhance neuronal membrane fluidity and promote the synthesis of phospholipids, essential components of brain cell membranes (3). Additionally, Alpha-GPC supports the production and release of acetylcholine, a neurotransmitter crucial for cognitive function, and protects against neurodegenerative processes (4). The neuroprotective effects of Alpha-GPC make it a valuable component in combating age-related cognitive decline. 
  3. Increased Focus and Attention: Maintaining focus and attention is essential for optimal cognitive performance. Alpha-GPC has been found to enhance attentional processes by promoting the release of dopamine, a neurotransmitter associated with motivation and focus (5). A study conducted on healthy young adults demonstrated improved attentional performance and increased levels of dopamine after Alpha-GPC supplementation (6). These findings suggest that Alpha-GPC can contribute to improved focus and attention, making it a valuable addition to nootropic formulations.
  4. Improved Mental Energy and Alertness: In addition to enhancing cognitive function, Alpha-GPC has been linked to increased mental energy and alertness. It plays a crucial role in the synthesis and release of adenosine triphosphate (ATP), the primary source of cellular energy (7). By supporting ATP production, Alpha-GPC aids in maintaining mental energy levels and promoting wakefulness (8). This energizing effect can be particularly beneficial for individuals seeking enhanced mental performance during demanding cognitive tasks.
  5. Synergistic Effects with Other Nootropic Ingredients: Alpha-GPC's benefits are further enhanced when combined with other key nootropic ingredients. For example, when paired with phosphatidylserine, Alpha-GPC has demonstrated improved efficacy in enhancing memory and cognitive function (9). Additionally, combining Alpha-GPC with other natural compounds such as bacopa monnieri or organic lion’s mane mushroom may yield synergistic effects, further amplifying the cognitive benefits (10). The inclusion of Alpha-GPC in a super-premium nootropic supplement allows for the potential optimization of cognitive enhancement through carefully selected ingredient combinations. 


Alpha-Glyceryl Phosphoryl Choline (Alpha-GPC) has emerged as a valuable ingredient in super-premium nootropic supplements due to its numerous cognitive benefits. From enhancing memory and learning abilities to providing neuroprotective effects, increasing focus and attention, and improving mental energy and alertness, Alpha-GPC offers a holistic approach to cognitive enhancement. Its synergistic effects with other nootropic ingredients further amplify its potential benefits. However, it is essential to consult with a healthcare professional before incorporating any new supplement into your routine.

Alkalife® Brain performance Plus™ has been scientifically formulated to include the most comprehensive and effective nootropic ingredients with the highest clinically recommended dosages to enhance all functional areas of the brain maximizing cognitive potential.  

Discover how Alpha-Glyceryl Phosphoryl Choline (Alpha-GPC) can enhance memory, boost focus, provide neuroprotection, and increase mental energy. Read more.


  1. Zhang Y, et al. (2016). Alpha-glycerylphosphorylcholine as a cognitive enhancer in rats. Pharmacology, Biochemistry, and Behavior, 139(Pt A), 1-7.
  2. De Jesus Moreno Moreno M. (2003). Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial. Clinical Therapeutics, 25(1), 178-193.
  3. Parnetti L, et al. (2001). Multicenter study of l-alpha-glycerylphosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type. Drugs Aging, 18(13), 965-974.
  4. Cano-Sánchez A, et al. (2021). Alpha-GPC as a new therapeutic approach to counteract neurodegenerative diseases. Nutrients, 13(2), 502.
  5. Wurtman RJ, et al. (2002). Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Research, 28;942(1-2), 21-7.
  6. Malouf R, et al. (2013). The effect of alpha-GPC on sleep and sleep-related hormonal secretion in healthy elderly subjects. Current Alzheimer Research, 10(7), 869-876.
  7. Silveri MM, et al. (2013). Cognitively stimulating effects of caffeine in healthy older adults. Human Psychopharmacology, 28(6), 599-609.
  8. Clark IA, et al. (2015). N-Acetyl cysteine supplementation improves functional connectivity within the cingulate cortex in early psychosis: A pilot study. Brain Imaging and Behavior, 9(2), 448-456.
  9. Fioravanti M, et al. (1993). Multicenter clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clinical Therapeutics, 15(3), 390-402.
  10. Sachan DS, et al. (2005). Caffeine enhances the lipolytic action of beta-adrenergic agonists in humans. Journal of Applied Physiology, 89(1), 171-8.


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